{"id":8548,"date":"2025-04-16T10:34:00","date_gmt":"2025-04-16T02:34:00","guid":{"rendered":"https:\/\/hesp.tcu.edu.tw\/?p=8548"},"modified":"2025-07-01T10:40:44","modified_gmt":"2025-07-01T02:40:44","slug":"8548","status":"publish","type":"post","link":"https:\/\/hesp.tcu.edu.tw\/?p=8548","title":{"rendered":"\u904b\u52d5\u795e\u7d93\u5143\u75be\u75c5\u7684\u6a5f\u5236\u548c\u6cbb\u7642\u65b9\u6cd5\uff1aSMA\u548cALS"},"content":{"rendered":"<figure id=\"attachment_8549\" aria-describedby=\"caption-attachment-8549\" style=\"width: 1024px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"size-large wp-image-8549\" src=\"https:\/\/hesp.tcu.edu.tw\/wp-content\/uploads\/2025\/07\/0416-\u904b\u52d5\u795e\u7d93\u5143\u75be\u75c5\u7684\u6a5f\u5236\u548c\u6cbb\u7642\u65b9\u6cd5-1024x768.jpg\" alt=\"\" width=\"1024\" height=\"768\" srcset=\"https:\/\/hesp.tcu.edu.tw\/wp-content\/uploads\/2025\/07\/0416-\u904b\u52d5\u795e\u7d93\u5143\u75be\u75c5\u7684\u6a5f\u5236\u548c\u6cbb\u7642\u65b9\u6cd5-1024x768.jpg 1024w, https:\/\/hesp.tcu.edu.tw\/wp-content\/uploads\/2025\/07\/0416-\u904b\u52d5\u795e\u7d93\u5143\u75be\u75c5\u7684\u6a5f\u5236\u548c\u6cbb\u7642\u65b9\u6cd5-300x225.jpg 300w, https:\/\/hesp.tcu.edu.tw\/wp-content\/uploads\/2025\/07\/0416-\u904b\u52d5\u795e\u7d93\u5143\u75be\u75c5\u7684\u6a5f\u5236\u548c\u6cbb\u7642\u65b9\u6cd5-768x576.jpg 768w, https:\/\/hesp.tcu.edu.tw\/wp-content\/uploads\/2025\/07\/0416-\u904b\u52d5\u795e\u7d93\u5143\u75be\u75c5\u7684\u6a5f\u5236\u548c\u6cbb\u7642\u65b9\u6cd5-1536x1152.jpg 1536w, https:\/\/hesp.tcu.edu.tw\/wp-content\/uploads\/2025\/07\/0416-\u904b\u52d5\u795e\u7d93\u5143\u75be\u75c5\u7684\u6a5f\u5236\u548c\u6cbb\u7642\u65b9\u6cd5-2048x1536.jpg 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption id=\"caption-attachment-8549\" class=\"wp-caption-text\">\u6587\/\u7167\u7247\uff1a\u7814\u7a76\u767c\u5c55\u8655<\/figcaption><\/figure>\n<p>114\u5e744\u670816\u65e5\u6148\u6fdf\u5927\u5b78\u7814\u7a76\u767c\u5c55\u8655\u5b78\u8853\u7814\u7a76\u7d44\u8209\u8fa6\u5c08\u984c\u6f14\u8b1b\uff0c\u672c\u6b21\u6f14\u8b1b\u9080\u8acb\u7f8e\u570b\u5357\u52a0\u5927\u751f\u7269\u79d1\u5b78\u7cfb\u795e\u7d93\u751f\u7269\u5b78\u7d44\u67ef\u7c21\u8a55\u6559\u6388(Chien-Ping KO, PhD)\uff0c\u900f\u904e\u6f14\u8b1b\u4e3b\u984c\u300c\u904b\u52d5\u795e\u7d93\u5143\u75be\u75c5\u7684\u6a5f\u5236\u548c\u6cbb\u7642\u65b9\u6cd5\uff1aSMA\u548cALS\u300d\uff0c\u53ef\u6709\u6548\u63d0\u5347\u8207\u6703\u8005\u5c0d\u810a\u9ad3\u6027\u808c\u8089\u840e\u7e2e\u75c7\uff08SMA\uff09\u53ca\u808c\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\uff08ALS\uff09\u7b49\u904b\u52d5\u795e\u7d93\u5143\u75be\u75c5\u4e4b\u75c5\u7406\u6a5f\u8f49\u8207\u6700\u65b0\u6cbb\u7642\u9032\u5c55\u7684\u7406\u89e3\u3002\u6d3b\u52d5\u7d50\u5408\u81e8\u5e8a\u8207\u57fa\u790e\u7814\u7a76\u89c0\u9ede\uff0c\u4e0d\u50c5\u4fc3\u9032\u91ab\u7642\u8207\u7814\u7a76\u4eba\u54e1\u4e4b\u9593\u7684\u77e5\u8b58\u4ea4\u6d41\uff0c\u4e5f\u5f37\u5316\u8de8\u9818\u57df\u5408\u4f5c\u5951\u6a5f\u3002\u6b64\u5916\uff0c\u85c9\u7531\u5c08\u5bb6\u6df1\u5165\u6dfa\u51fa\u7684\u5206\u4eab\uff0c\u6709\u52a9\u65bc\u63d0\u9ad8\u5c0d\u7f55\u898b\u795e\u7d93\u75be\u75c5\u7684\u91cd\u8996\uff0c\u9032\u800c\u63a8\u52d5\u672a\u4f86\u5728\u8a3a\u65b7\u6280\u8853\u3001\u6cbb\u7642\u7b56\u7565\u53ca\u75c5\u60a3\u7167\u8b77\u4e0a\u7684\u767c\u5c55\u8207\u5275\u65b0\u3002<\/p>\n<p>\u8b1b\u5e2b\u4ee5\u8c50\u5bcc\u7684\u7814\u7a76\u6210\u679c\uff0c\u4ecb\u7d39\u810a\u9ad3\u808c\u8089\u840e\u7e2e\u75c7\uff08SMA\uff09\u8207\u808c\u840e\u7e2e\u810a\u9ad3\u5074\u7d22\u786c\u5316\u75c7,\u808c\u840e\u7e2e\u5074\u7d22\u786c\u5316\u75c7,\u6f38\u51cd\u4eba\u75c7\uff08ALS\uff09\u5169\u7a2e\u904b\u52d5\u795e\u7d93\u5143\u75be\u75c5\u7684\u75c5\u7406\u6a5f\u5236\u53ca\u6700\u65b0\u6cbb\u7642\u9032\u5c55\u3002\u9996\u5148\u8aaa\u660e SMA \u662f\u4e00\u7a2e\u67d3\u8272\u4f53\u96b1\u6027\u907a\u50b3\u75be\u75c5\uff0c\u662f\u5b30\u5152\u6b7b\u4ea1\u6700\u5e38\u898b\u7684\u55ae\u57fa\u56e0\u539f\u56e0(\u7f55\u898b\u75be\u75c5)\uff0c\u5728\u7f8e\u570b\u670925,000\u540d\u60a3\u8005\u3001\u5728\u53f0\u7063\u7d04\u6709400\u540d\u60a3\u8005\uff0c\u4e26\u9032\u4e00\u6b65\u63a2\u8a0e SMN2 \u57fa\u56e0\u7684\u526a\u63a5\u7570\u5e38\u5c0d\u75c5\u60c5\u56b4\u91cd\u5ea6\u7684\u5f71\u97ff\uff0c\u5728ALS\u90e8\u5206\uff0c\u8b1b\u5e2b\u805a\u7126\u65bcUNC13A\u57fa\u56e0\u932f\u8aa4\u526a\u63a5\u8207TDP-43\u86cb\u767d\u7570\u5e38\u7684\u95dc\u806f\uff0c\u4e26\u5c55\u793a\u4e86\u7531AcuraStem\u5718\u968a\u958b\u767c\u4e4bUNC13A\u53cd\u7fa9\u5be1\u6838\u82f7\u9178\uff08ASO\uff09\u7684\u7814\u7a76\u6210\u679c\u3002\u8a72\u7642\u6cd5\u53ef\u6709\u6548\u963b\u6b62UNC13A\u7684\u96b1\u6027\u5916\u986f\u5b50\u932f\u8aa4\u526a\u63a5\uff0c\u6062\u5fa9\u86cb\u767d\u8868\u9054\u8207\u7a81\u89f8\u529f\u80fd\uff0c\u5c55\u73fe\u672a\u4f86\u4f5c\u70ba ALS \u75be\u75c5\u6539\u8b8a\u6cbb\u7642\uff08disease-modifying therapy\uff09\u4e4b\u6f5b\u529b\u3002<\/p>\n<p>\u672c\u6b21\u6f14\u8b1b\u5167\u5bb9\u8c50\u5bcc\uff0c\u6a6b\u8de8\u907a\u50b3\u5b78\u3001\u795e\u7d93\u751f\u7269\u5b78\u3001\u85e5\u7269\u958b\u767c\u8207\u81e8\u5e8a\u7814\u7a76\u7b49\u591a\u500b\u5c64\u9762\uff0c\u5438\u5f15\u8a31\u591a\u6559\u5e2b\u8207\u5b78\u751f\u53c3\u52a0\uff0c\u6f14\u8b1b\u7d50\u675f\u5f8c\u5e2b\u751f\u5011\u4e5f\u5f88\u8e34\u8e8d\u56de\u994b\u8207\u63d0\u554f\u7c21\u5831\u5167\u5bb9\uff0c\u671f\u5f85\u85c9\u7531\u6b64\u6b21\u6f14\u8b1b\u672c\u6821\u5e2b\u751f\u8207\u8b1b\u5e2b\u5b78\u8853\u5408\u4f5c\u7684\u53ef\u80fd\u6027\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>114\u5e744\u670816\u65e5\u6148\u6fdf\u5927\u5b78\u7814\u7a76\u767c\u5c55\u8655\u5b78\u8853\u7814\u7a76\u7d44\u8209\u8fa6\u5c08\u984c\u6f14\u8b1b\uff0c\u672c\u6b21\u6f14\u8b1b\u9080\u8acb\u7f8e\u570b\u5357\u52a0\u5927\u751f\u7269\u79d1\u5b78\u7cfb\u795e\u7d93\u751f\u7269\u5b78\u7d44\u67ef\u7c21\u8a55 [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":8549,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22,44,45],"tags":[],"class_list":["post-8548","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sdg-4-","category-44","category-45"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/hesp.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/8548","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hesp.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hesp.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hesp.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/hesp.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=8548"}],"version-history":[{"count":2,"href":"https:\/\/hesp.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/8548\/revisions"}],"predecessor-version":[{"id":8552,"href":"https:\/\/hesp.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/8548\/revisions\/8552"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/hesp.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/media\/8549"}],"wp:attachment":[{"href":"https:\/\/hesp.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=8548"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hesp.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=8548"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hesp.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=8548"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}